| Title | [A case of light chain deposition disease involving kidney and bone marrow with microangiopathic hemolytic anemia.] | | Author(s) | Cho YU, Chi HS, Park CJ, Jang S, Cho YM, Park JS | | Institution | Department of Laboratory Medicine, Eulji University School of Medicine, Eulji General Hospital, Seoul, Kerea. | | Source | Korean J Lab Med 2009 Oct; 29(5):384-9. | | Abstract | We report a case of light chain deposition disease in a 59-yr-old female showing deposition of monoclonal light chain in the kidney and bone marrow accompanied with a schistocytosis, the morphologic finding of microangiopathic hemolytic anemia. The immunofluorescence examination of the kidney revealed strongly stained kappa-light chain deposits on the glomerular mesangium and capillary wall, tubules, and vessel wall. The electron microscopy demonstrated electron-dense deposits on the glomerular basement membrane and mesangium. Anemia was observed with schistocytosis and Howell-Jolly body in the peripheral blood smears. The immunohistochemical examination of the bone marrow showed the presence of kappa-light chain deposits in scattered plasma cells and thickened vessel wall in the absence of a prominent plasma cell proliferation. Although an immunofixation electrophoresis failed to detect a monoclonal gammopathy, the presence of monoclonal protein could be identified by an abnormal kappa/lambda ratio on the serum free light chain analysis. | | Language | kor | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 19893345 |
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